We often come across many changes in our lives, that result in stress. All this lead to factors that cause changes in our bodies, leading to a very threatening life events.
What cause stress
Being stressed is a response of your body to any environmental extremely triggers by changes or intsense social interaction. This may also result from subtle social contacts or from a lack of social contact.
Thus, a person who is socially isolated may experiences stress as much as one who is anxious, fearful, or angry.
How to recognize one with stress
A person experiencing stress may appear abnormal pale (pallor) and have cool skin and a dry mouth.The intensity of a stress response can be judged by observing changes in a person’s heart rate, respiratory rate, blood pressure, and perspiration on the palms of the hands.
It can furthermore, be measured by determining the concentration of epinephrine or cortisol in the blood or urine.
Concentration of cortisol in blood
For some reasons that are poorly understood, the increased secretion of cortisol may be accompanied by a decrease in the activities of the lymphatic organs (organs that make sure that our body cells are clean and all dirt or debris are removed completely).
Lymphatic organs that maybe involved
Such organs may include thymus, lymph nodes, and spleen. At the same time, the number of lymphocytes in the blood tends to decrease. Since these white blood cells defend the body against infection, a person who is under stress may have a lowered resistance to infectious diseases.
In addition, the exposure to excessive amounts of cortisol may promote the development of high blood pressure drjiyanemedicalhelp.com/diabetes-mellitus-and-ketones, atherosclerosis, and gastrointestinal ulcers.
What other people come across
Most us we experiences some degree of stress as a result of disease, pain, anxiety, or even the medical treatments they are receiving.
Types of stress
Physical stress can be reduced by providing yourself with a pleasant, comfortable external surroundings and by helping further helping yourself maintain a stable internal environment by controlling pain, administration of necessary fluids and electrolytes, sick drugs or treatmentent for infection and so forth.
Stress can come in any form, it can be physical stress through pain or and infection. It may also include psychological factors such as lot of things that cause mental disturbances.
Stress has no age, some children are born with stress but easily monitored and eliminated. As old as one can be, stress can strike. Taking care of your surroundings and internal being is the only way to do away of stress.
Diabetis mellitus is characterized by a deficiency of insulin (hypoinsulinism) and by severe disturbances in carbohydrates metabolism as well as by disorders in protein and fat metabolism.
More specifically, the movement of glucose into adipose and skeletal muscle cells decreases, glycogen formation decreases, and consequently the concentration of blood sugar rises (hyperglycemia).
When the blood sugar reaches a certain high concentration, the kidneys begin to excrete the excess, and glucose appears in the urine (glycosuria). The presence of sugar raises the osmotic pressure of the urine, and more water and electrolytes are excreted than usual.
As a result of excessive urine output (diuresis, or polyuria), the affected person becomes dehydrated and experiences great thirst (polydipsia).
The background of the name
The name of this condition is derived from “diabetes“, referring to the increased output of urine, and the term “mellitus” referring to honey in a Latin, thus furthermore referring to its sugar content.
Some of symptoms of diabetic individuals
Diabetes mellitus is accompanied by the decreases in the synthesis of protein and fats. As a result of decreased protein synthesis, and increased use of protein as an energy source by glucose-starved cells, tissues tend to waste away. The affected individuals are said to lose weight rapidly and have a decreased ability to grow or repair damaged tissues.
The accumulation of fats and ketones
As a result of decreased fat synthesis and storage, fatty acids tend to accumulate in the blood abnormally. At the same time, ketone bodies increases in the blood, causing a condition called ketosis. Ketones are a by-product of fats metabolism, and they can be excreted in the urine (ketonuria) in the form of sodium salts.
However, when ketones are excreted, large quantities of water follow them osmotically. This water loss intensifies the dehydration of the tissues, and the loss of sodium salts causes the sodium ion concentration to decrease.
The accumulation of acidic high blood sugar ketone bodies in the blood and the loss of sodium ion leads to metabolic acidosis. Metabolic acidosis Isa condition in which the pH of the body fluids decreases.
As a result of acidosis and dehydration, neurons in the brain are adversely affected, and without treatment, the person may become disoriented, comatose (diabetes coma), meaning that person go to coma and die.
Two common diabetes mellitus
There are two well known types of diabetes mellitus, this includes insulin-dependent diabetes mellitus also know as type-1, or juvenile onset diabetes mellitus and noninsulin-dependent diabetes mellitus which is also known as type-2 or maturity onset diabetes mellitus.
Insulin-dependent diabetes mellitus (IDDM), usually appears before the age of twenty. It is an autoimmune disease, in which the body’s immune system slowly causes the beta cells of the pancreas to be damaged and finally destroyed, so that the ability to secrete insulin is lost.
Treatmentent of diabetes mellitus
The usual treatment of this form of diabetes include administration enough insulin to control carbohydrates metabolism. However, such therapy almost never achieves the blood glucose stability found in a healthy person.
Since insulin is a protein and is broken down by digestive enzymes, it must be administered parenterally- that is , by some route other than the alimentary canal, usually by injection.
The amount and type of insulin needed varies with individuals, depending on such factors as diet, physical activities, and health.
2. Noninsulin-dependent diabetes mellitus (NIDDM)
None insulin dependent diabetes mellitus individuals is found in 70 -80 percent of diabetic patients. It usually appears gradually during adulthood (after the age of forty) and produces mildly symptoms that the other form.
It is thought to be formed or caused by an inherited disorder, although most people who are affected are overweight when they first experience the symptoms.
In this condition, the beta cells continue to function, in fact the patiant may have an excessive blood insulin, the symptoms of noninsulin-dependent diabetes mellitus seems to involve a loss of sensitivity to the hormone, apparently due to a decreased number of insulin receptors in the target cells.
Treatment of this form of diabetes usually involves a carefully controlling of the diet, participating in an exercise program, avoiding substances that stimulates insulin secretion, and maintenaning a desirable body weight.
Testing diabetes mellitus
A test commonly used to diagnose diabetes mellitus is the glucose-tolerance test. To perform the test, the patient ingests a specific amount of glucose, and the blood glucose concentration is measured at interval to determine how the glucose is utilized.
In a person with diabetes, the blood glucose concentration will rise excessively and remaining elevated for several hours. In a normal person, the glucose rises to a lesser degree and returns to its normal concentration in about one and one-half hours.
The goal of diabetes mellitus treatment
The major goal of the diabetes mellitus treatment to a patient is to keep the blood glucose concentration under control, regular monitoring of blood glucose is usually necessary.
Such testing may be done by a patient at home using a drop of capillary blood and a strip of blood glucose test paper or a blood glucose meter. The results of these tests indicate the blood glucose concentration at the time of the tests.
Another more complex method for determining a patient’s blood glucose concentration involves a laboratory blood tests for hemoglobins A. This test measures a patient’s average blood glucose concentration for the preceding sixty days.
Diabetes mellitus have no age restriction, one can be born diabetic, and that we called inherited diabetes, which is characterized by a certain Gene disorder that is running in a family.
Another diabetes maybe the acquired one, of which is the one that is caused by unhealthy reach or poor life style. This one is base on the dietary needs.
Many test are available shops, such as diabetes tests kits, diabetes supplies, diabetes mellitus strips and diabetes test meters. You can also undergo laboratory way, in which you will wait a little longer for your tests results.
Diabetes mellitus is not treatable but is controllable and easily monitored by insulin treatment or by just diet and exercise programs.
Did you know that joints are subjected to many considerable stress due to several factors? The are used frequently, and they must provide for a great variety of body movements.
Some of them must support body weight. Injuries such as dislocations and sprains occur commonly during strenuous physical activities. In addition, joints may be affected by inflammation as well as by a number of degenerative diseases such as arthritis.
A dislocation (luxation) involves the displacement of the articulating bones of a joint. This condition usually occurs as the result of a fall ( meaning if you happen to fall this disorder may result) or some other unusual body movement.
The joints of the shoulders, knees, elbows, fingers, and jaw are common sites for such an injuries. A dislocation is characterized by an obvious deformity of the joint, some loss of ability to move the parts involved, localized pain, and swelling. It presents a severe physical problem and requires medical attention.
Sprains are the result of overstretching or tearing the connective tissues, ligaments, and tendons associated with a joint, but without dislocating the articular bones. Usually sprains are caused by forceful wrenching or twisting movements involving joints of the wrists or ankles.
For example, the ankle may be sprained if it is inverted excessively when running or jumping, causing the ligaments on its lateral surface to be stretched. In severe injuries, these tissues may be pulled loose from their attachments.
A sprained joints is likely to be painful and swollen, and movement at the joint may be restricted. The immediate treatment for a sprain is rest; more serious cases require medical attention.
However, immobilization of a joint, even for a relatively shirt period, results in resorption of bone tissue and weakening of ligaments. Consequently, following such treatment, exercises may be needed to help strengthened the joint.
Bursitis is an inflammation of a bursa that may be caused by excessive use of a joint or by stress on a bursa. For example, the Bursa between the heelbone (calcaneus) and the Achilles tendon may become inflamed as a result of a sudden increase in physical activity involving the use of the feet.
Similarly, a form of bursitis called “tennis elbow” involves the bursa between the olecranon process and the skin. Generally, bursitis is treated with rest, although severe cases may need medication.
Arthritis is an infection that lead to a disease condition that causes inflamed, swollen, and painful joints. Although there are several types of arthritis, the most prevalent or common forms are rheumatoid arthritis and osteoarthritis.
1. Rheumatoid arthritis
It is an autoimmune disease and is the most painful and potentially crippling of the arthritic conditions. In this type of arthritis, the synovial membrane of a joint becomes inflamed and grows thicker, forming a mass called a pannus.
This change is usually followed by damage to the articular cartilages of the joint and by an invasion of the joint by fibrous tissues. These tissues interfere increasingly with joint movements, and , in time, they may become ossified so that the articulating bones become fused together (bony avnkylosis).
The rheumatoid arthritis may affect many joints or only a few. It may be accompanied by the development of other disorders, including anemia, osteoporosis, and muscular atrophy as well as abnormal changes in the skin, eyes, lungs, blood vessels, and heart.
Although e mechanism by which joints are damaged in rheumatoid arthritis is not well understood, it seems to involve the presence of certain white blood cells (chronic inflammatory cells, such as lymphocytes and monocytes).
These cells release substances (cytokines) that stimulate osteoclastic activities, which , in turn, can cause destruction of bone tissue.
2. Osteoarthritis (degenerative joints disease)
This is the most common type of arthritis. It occurs ad a result of ageing, as well as certain other factors, and affects a large proportion of the population over fifty years of age.
In this condition, the articular cartilages soften and disintegrate gradually, so that the articular surfaces become roughened. Consequently, the joints involved ate painful, and their movement is somewhat restricted.
The osteoarthritis is most likely to affect joints that have received the greatest use over someone’s lifetime, such as those of the fingers, hips, knees, and the lower regions of the vertebral column.
Other factors that seem to increase the chances of developing osteoarthritis include joint injuries, excess body weight, and certain metabolic disorders.
As a rule, osteoarthritis develops relatively slowly, and its symptoms may be controlled by medication. In !ore severe cases, joints functions are disrupted, and parts of joints may need to be replaced surgically.
If you happened to feel severe pain and loss of knee joint function as a result of rheumatoid arthritis or osteoarthritis. You need to receive a knee replacement.
During this surgical procedure called total knee atthroplasty, the damage surfaces of the distal femur are removed and replaced with a smooth surface metallic device.
Similarly, the proximal surface of the tibia is removed and replaced by a device consisting of low friction polyethylene attached to a metal plate. The metallic parts of these devices are connected to the bones by means of pegs, screws, or bone cement.
Obesity and athletic activities
In addition to causing fractures, the excessive mechanical stress due to obesity or certain athletic activities may damage the articular cartilage of various joints and cause it to deteriorate. Joints that are subjected to the repeated overloading, as in the elbows of a baseball pitcher or the knee of a basketball player, are likely to develop the degenerative joint diseases called osteoarthritis.
Although degeneration of the cartilage may be reversed when joints movements are resumed, it is important to avoid exercises that cause excessive compression of the tissue during the period of regeneration. Otherwise, further injuries may occur and the repair process may be hindered.
The joints disorders are not just restricted to a certain group of people age. It is a disease that is cause by an infection sometimes but yes age matter.
To correct problems caused by joint injuries or diseases, it is sometimes desirable to replace e articulating parts with artificial (prosthetic) devices.
The virus is a set of gene. Typical viruses multiplication cycle is divided into six phases: 1. Absorption to the human cell, which is referred to as host cell; 2. Penetration or entry to the human cell; 3. Uncoating to release the genomes; 4. Viruses or virion components production; 5. Assembly; and 6. Released from the human cell.
This series of events, sometimes with a slightly variation. The viral infection of the cells may be productive (lytic response) or nonproductive (no response).
The outcome of an infection depends on the particular virus-host combination. This means, it depends on the relationship, the viruses have with our body cells.
The viruses need to undergo only one stage between the productive and nonproductive. This kind of viruses are called virulent virus or angry virus.
Those viruses that can undergoes both productive and nonproductive, are referred to as temperate viruses. Some of the temperate viruses can be reactivated or induced to leave a latent state (sleeping state), and they enter to a productive state or virulent stage.
The remainder of this article is concerned with the details of the steps of the virulence state. The next article will jump to routes of infectious diseases transmission.
The first steps for viruses to multiply in any viral infections is the attachment known as adsorption of the infecting particles to the surfaces of the cell.
The prerequisites for this interaction is a collision between the virus and the human cell. Only a small fraction of the collisions between a virus and its host cell lead to a successful infections.
The viruses need to have attachment proteins known as receptors. These receptors are more similar to human fingers and hands for grabbing. This is because the virus uses these receptors to attach on human cell.
You still remember enveloped and naked viruses http://drjiyanemedicalhelp.com/genomic-structures-viruses-causing-infection-and-diseases/?
All enveloped viruses that are causing diseases in humans, contain the attachment proteins which are receptors. Some of the viral receptors are also found on human red blood cells of certain species. Such receptors are responsible for hemagglutination.
The particular kind of a virus is capable of inflecting only a limited spectrum of of cell types called its host range. This kind of cell host range is very important in determining the pathology of the infection ( the steps in which the virus under go in order to cause an infection).
The entry and uncoating
Once the virus has attached on the human cell, penetration which is the entry into the inside of the cell, the virus is no hidden from the immune system.
The uncoating stage happens simultaneously with the entry or may happened in series of steps. Here we will discuss two type of viral entry and uncoating.
1. The enveloped human viruses
Two basic mechanisms for the entry of an enveloped human viruses into the cell. Both of the mechanisms involve fusion of the viral envelope with a cellular membrane, and the release of the free nucleic capsid into the cytoplasm.
The envelopes of these viruses contain protein spikes (hands finger like) that promote fusion of viral envelopes with the plasma membrane of the cell, releasing e nucleic capsid directly into the cytoplasm.
2. The naked capsid human viruses
Viruses may undergoes dissolution, getting dissolved by binding on the human cell membrane or skin. The nuclei acid is directly deposited to the targeted sites. Now let get to refresh our understand, that viruses are separated into RNA viruses and DNA viruses.
So, most RNA viruses replicate or multiply on the cytoplasm, with the exception of influenza virus (flue) and the retrovirus (HIV). Influenza virus, retrovirus, and other DNA viruses except poxvirus replicate or multiply in the nucleus of the human cell.
Genomic structures replication (multiplying)
The human cells obviously contain the enzymes and tons of protein accessories required for the replication of the DNA.
The smallest DNA viruses like parvovirus, they depends on the infected human cell so that if that infected cell divide thus the virus divide too.
This also occurs with some of RNA viruses, the good example of this kind is HIV. That is the reason why it is not easy to clear or eliminate it. Topic on HIV will be discussed in depth later.
Assembly of viral particles
Remember that we said one human cell is infected by a virus and human cells are naturally multiplying by division. So now the virus is inside the cell that is prone to multiply by division.
The genomes of the viruses and that of the human cell are now one (integrated), the first thing to divide is the cytoplasm, which is a fluid inside the cell. Followed by the nucleus inside the cell. Once all of this is done.
The overall cell divides with the the virus in it. So now more of the infected human cells are thus produced.
Assembly stage the place when each of the new cell’s proteins are coming together to make new infected cells. Note: it is not simple as in this generalization to describe this phenomenon.
Release of new viruses
Once the viral particles have been assembly, now new baby viruses causing infection and diseases are ready to be released from the mother host cell.
This all happens by escape from the infected cell through coding for enzymes that lysis the cell. These enzymes weaken the cell wall by cleaving specific bonds in peptidoglycan layer. The weakened cells burst as a result of the osmotic pressure.
Human viruses are furthermore released as follows:
1. Cell death
The mother infected cell or host infected cell dies after giving birth to the new infected cells or viruses.
Presumably because the viral genetic program is dominant and precludes the continuation of normal cell functions required for survival.
The naked capsid human viruses lack specific mechanisms for lysing the infected cell and apparently are released into the extracellular milieus simply as a consequence of cell death.
With the exception of other viruses, all enveloped human viruses acquire their membrane by budding either through the plasma membranes. In the case of herpes viruses, ultimately escape from the cell after budding through nuclear membrane is unclear (more research is required).
For viruses that bud, it is important to note that the plasma membranes of the infected cells contains virus-specific glycoproteins that represent foreign antigens. This means your infected cells become the target of your own immune system.
Protection from viral infection is to be accomplished at the level of antibodies binding to the viruses, it must occur before adsorption and prevent viruses from attaching to and penetrating our cells.
Most enveloped viruses acquire an envelope during released by budding. Retroviruses except HIV reproduce without cell death.
The spread of diseases is essential to all medical personnel, whether their work is with the individual patient or with the community. Most infections must be evaluated in their epidemiological settings.
For example, has the patient recently traveled to an area of special disease prevalent? Is there a possibility of nosocomial infection ( infection that you acquired as you enter the hospital doors either ad a visitor or as an admitted patient) from recent hospitalization? What is the risk to the patient’s family, schoolmates, and work or social contacts?
Infectious diseases of humans may be caused by exclusively human pathogens/ microorganisms, such as the Measles viruses, by environmental microorganisms such as Legionella pneumophila,or by microorganisms that have their primary reservoir in animals such as the plague bacillus.
They can generally be classified as noncommunicable or communicable.
Noncommunicable infections are those that are not transmitted from human to humans and include:
1. Infections derived from the patient’s normal flora or microflora such as peritonitis after rupture of the appendix;
2. Infections caused by the ingestion of preformed toxins, such as Botulism; and
3. Infections caused by certain microorganisms found in the environment, such as Clostridial gas gangrene.
Noncommunicable infections may still occur as common source outbreaks, such as food poisoning from an enterotoxin producing Staphylococcus aureus contaminated chicken salad or multiple cases of pneumonia from extensive dissemination of Legionella through an air conditioning system.
As these diseases are not transmissible to others, they do not lead to secondary spread.
Communicable infections are transmissible from one person to the next person. They can be endemic, which simple means that the diseases are present at a low but fairly constant level, or epidemic, which now involves a level of infection above that usually found in a community or population.
Communicable infections may be widespread in a region and sometimes world wide with a high attack, in which case they are termed pandemic. A communicable infection requires that microorganisms to be able to leave the body in a form that either is directly infectious to others or is able to become so after development in a suitable environment.
An example of direct communicability is the respiratory spread of the Influenza viruses. In contrasts, the Malarial parasite requires a developmental cycle in a biting mosquito before another human being can be infected.
Infections and diseases
Infections involves multiplication of the microorganisms in or on the host and can be inapparent, for example, during the incubation period.Diseases are represented by a clinical apparent response by or injury to the host as a result of infection.
With many communicable microorganisms, infection is much more common than diseases, and apparently healthy infected individuals play an important role in disease propagation. Inapparent infections ate termed subclinical, and the individual is sometimes referred to as a carrier.
For example, the clinical inapparent presence of Staphylococcus aureus in the anterior nares is termed carriage, as is a chronic gallbladder infection with Salmonella typhoid that can follow an attack of typhoid fever and result in fecal excretion of the microorganisms for years.
With some infectious diseases, such as measles, infection invariably accompanied by clinical manifestations of the disease itself. These manifestations facilitate epidemiologic control, because the existence and extent of infection in a community are readily apparent.
Microorganisms associated with long incubation periods or high frequencies of subclinical infections like HIV or Hepatitis B viruses may propagate and spread in a population for long periods before the extent of the problem is recognized. This makes communicability control more difficult.
The incubation period and communicability
The incubation period is the time between exposure to the microorganisms and appearance of the first symptoms of the diseases.
Generally, microorganisms that multiply rapidly and produce local infections, such as Gonorrhea and influenza , are associated with short incubation periods (eg.2-4 days).
Diseases such as typhoid fever, which depends on hematogenous spread and multiplication of the microorganisms in distant target organs to produce symptoms, often have longer incubation periods.
Some diseases have even more prolonged incubation periods because of slow passage of the infecting microorganisms to the target organ, as in rabies or slow growth of microorganisms such as that of Tuberculosis.
Incubation periods for one agent may also vary widely depending on route of acquisition and infecting dose. For example, the incubation period of hepatitis B virus infection may vary from 7 to more than 200 days.
Communicability of a disease in which the microorganism is shed in secretions may occur primarily during the incubation period. In other infections the disease course is short but the microorganisms can be excreted from the host for extended periods of time.
In yet other cases, the symptoms are related to the host immune response tether than the microorganisms action, and thus the diseas process may extend far beyond the period in which the etiologic agent can be isolated or spread.
Some viruses can integrate into the host genomes http://drjiyanemedicalhelp.com/genomic-structures-viruses-causing-infection-and-diseases/ or survive by replicating very slowly in the presence of an immune response.
Such dormancy or latency is exemplified by the Herpesviruses, and in each case the microorganisms may emerge long after the original infection and potentially infect others.
The inherent infectivity and virulence of microorganisms are also important determinants of attack rates of diseases in a community.
In general, microorganisms of high infectivity spread more easily and those of greater virulence are more likely to cause diseases than subclinical infection.
The infecting dose of the microorganisms also varies with different microorganisms and thus influences the chance of infection and development of a disease
From previous page posted, we introduced the meaning of viruses, their sizes and design http://drjiyanemedicalhelp.com/what-makes-viruses-difficult-to-respond-on-treatment/ . Now on the next topic we will be looking at genome structure, of which is the one that make viruses very difficult to respond very well on treatment or get cleared from our system.
Viral genomics structure
Structural diversity among the viruses is the most obvious, when the make-up of the viral genomes is considered. Genomes can be made of ribonucleic acid (RNA) or deoxyrionucleic acids (DNA) and be either double stranded or single stranded.
For viruses with single-stranded genomics, the nucleic acid can be either of the same polarity (indicated by a + or – for a different polarity) from that of the viral messenger-RNA (mRNA) produced during the viruses causing infection and diseases.
Two types of genomics structure are known, the linear and the circular. Most viruses have a single nucleic acid molecules for their genomics structures, in some cases several pieces of nucleic acid constitute the complete genome.
Viruses as such have segmented genomes. One virus class which is retrovirus (e.g.HIV) carries two identical copies of its genomics structures and is therefore diploid.
This is what is rarely and complicated about HIV. A few viral genomes such as picornaviruses, hepatitis B virus, and adenoviruses contain covalently attached protein on the ends of the polynucleotide chains.
Viral genomics subunit structure of Capsids
The capsid of all viruses are composed of many copies of one or at most several kinds of protein subunits.This fact follows from:
1. All viruses code for their own capsid proteins, and it turns out that even if the entire coding capacity of the genomics structures were to be used to specify a single giant capsid protein, the protein would not be large enough to enclose the nucleic acid genomes.
This lead to multiple protein copies required. The simplest spherical virus contains 60 identical protein subunits.
2. Viruses are such highly symmetric structures that it is not uncommon to visualize naked capsid viruses in the electron microscope as a crystalline arrays.
The presence of many identical protein subunit in viral capsids or the existence of many identical spikes in the membrane of enveloped viruses has important implications for adsorption, hemagglutination, and recognition of viruses by neutralizing antibodies http://drjiyanemedicalhelp.com/microorganism-the-cause-of-infection-leading-to-a-disease/
Viruses genomics cylindrical shape
A cylindrical shape is the simplest structure for a capsid. The first virus to be crystallized and studied was a plant virus, which is tobacco mosaic virus (TMV).
The capsid of a TMV is shaped like a rod or, a cylinder, with the RNA genomics structure wound in a helix inside it. The capsid is composed of many copies of a single kind of protein subunit arranged in a closed packed helix, which places every subunit in the same microenvironment.
Because of the helical arrangement of the subunits, viruses that have this type of design are often said to have helical symmetry. Thus, the nucleocapsids of influenza, measles, mumps, rabies, and poxviruses are probably constructed with a helical arrangement of protein subunit in close association with the nucleic acid genomics structures.
The viruses genomics spherical shape
Construction of a spherical shaped virus similarly involves the packing together of many identical subunits, but in case the subunits are placed on the surface of a geometric solid called an icosahedron.
Because the icosahedron belong to the symmetric structural group, the spherically shaped viruses are said to have cubic symmetry (note that the term ‘cubic’, used in these contexts, has nothing to do with the more familiar shape called cube).
When viewed in the electron microscope, many naked capsid viruses and some nucleocapsids appear as spherical particles with a surface topology that makes it appear that they are constructed of identical ball-shped subunits.
These visible structures are referred to as morphological subunits. Morphological subunits are composed of either five or six individual protein molecules, each one referred to as a structural subunit, or promoter.
In the simplest case of a virus with a cubic symmetry, I’ve promoters are placed on each 12 vertices of the icosahedron forming a pentamer. While, the capsid is composed of a total of 60 promoters.
This arrangement places every promoter in the same microenvironment as every other promoter in the case of helical symmetry.To accommodate the larger cavity required by viruses with large genomics structures, the capsid’s contain many more promoters.
These viruses are based on a variation of the basic icosahedron in which the construction involves a mixture of pentamers and hexamers instead of only pentamers. A detailed description of is higher level of virus structure is beyond the scope of this text.
Special surface genomics structures
Many viruses have structures that protrude from the surface of the virion. These genomics structures are important for the two earliest steps of infection, adsorption, and penetration.
The examples of the surface structure include the spikes of adenovirus and the glycoprotein spikes found in the membrane of enveloped viruses.
Even viruses without obvious surface extensions probably contain short projections, which is more of the obvious spikes, are involved in the specific binding of the virus to the cell surface.
Classification of viruses causing infection and diseases in human
Table 1 Represent classification of RNA and DNA human viruses causing diseases
Table 1 present a classification scheme for human viruses that is based solely on their genomics structure. The viruses are arranged in order of increasing genomics structural size.
It is important to bear in mind that phylogenetic relationships cannot be inferred from this taxonomic scheme. The tables should not be memorized, but instead used as a reference guide to viruses structures.
The terminal protein molecules as well as other special genomics structures found in other viruses play key roles in the replication process.
In general, viruses with similar genomics structures exhibit similar replication strategies.
See the next article, where we will be discussing viruses multiplication, viral infection of cells may be productive or none productive, animal viruses may cause oncogenic transformation.
People get sick and die because of microorganisms. What are microorganisms? Microorganisms are normally known as germs in simple english.Microorganisms can not be seen by our necked eyes, we can only see them by the use of a microscopy.
When we talk of microorganisms, we simple talk about bacteria, viruses, fungi, and others http://drjiyanemedicalhelp.com/diversity-of-microorganisms-the-offense/ .
Microorganisms can be classified as bad and good. We have good microorganisms, that are used in our food, medicine and cleaning materials. We can also find very bad microorganisms that make humans, plants and animals sick.
Where can microorganisms be found?
Microorganisms can be found everywhere, all over human skin; inside ones mouth, and nose; sexual organs (private parts); inside the stomach and intestine; on our hands; food we eat; soil, air, and water.
Good microorganisms that are found as normal micro flora in our body, have an ability to harm us. Remember our body are made of sterile environment and none sterile environment.
So if the harmful microorganisms get access to the sterile part of our body such as blood circulatory system, that is where a person is defined as infected by microorganisms. At that stage it is not a diseases, it is just an infection.
What is an infection? An infection is defined by the present of a bacteria or any other microorganisms being a foreigner or an antigen in our body, where now antibodies which are normal known as body soldiers or defense system recognises antigens.
Human body defend itself from microorganisms
Human bodies are made of defense mechanism which is immune system. Immune system consists of antibodies and a lot of immune cascades which we are not going to talk about in this posts.
Our skin, mouth, eyes, noise, vagina and penis possesses first layer of defense mechanisms. Skin itself is our first protector/ barrier from foreign microorganisms. If the first immune barrier fails or over powered by microorganisms.
A broader discussion on immunology will cover this part of antibodies or immune system as a whole.
Microorganisms cause infections and diseases
Once the immunity fail to defend the body from these very bad microorganisms, the sickness begins. Once a person shows signsvand symptoms, it is when we use a term called disease.
A disease can be infectious or none infectious. The infectious diseases are caused by microorganisms such as viruses, very bad bacteria, very bad fungi and parasites.
Microorganisms that cause diseases are called pathogens. Pathogens have an ability to cause to cause infections that lead to diverse diseases.
For detailed information on viruses see Genomic structures: viruses causing infection and diseases
Microorganisms can enter the body through the four sites such as respiratory tract (mouth and nose) e.g. influenza virus that causes the flu. Gastrointestinal track (mouth oral cavity) e.g. vibrio cholerae which causes cholera.
Urogenital tract e.g. Escherichia coli which causes cystitis. Sex organs (vagina and penis) e.g. Neisseria gonorrhoeae which causes gonorrhea.
Where can microorganisms reside and multiply
Microorganisms are found every where in our planet and everywhere on/in our body except in sterile environment like blood circulatory system and central nerveous system (CNS).
In none sterile environment such as vagina, penis, anus, mouth, nose and skin, microorganisms can reside and multiply.
Viruses are microorganisms that can only survive and multiply inside leaving cells http://drjiyanemedicalhelp.com/diversity-of-microorganisms-the-offense/.
Mostly once a virus is inside a human cell, it incorporate it own DNA with that of a human cell to multiply and further infect other neighbouring cells, thus far initiate an infection that later become a disease if not diagnosed and get eliminated or treated early.
Bacterial microorganisms can survive and multiply in any environmental given. Such that, there are bacteria that survive in harsh temperatures, very hot conditions more than a thousand degrees Celsius.
Some bacteria can be found residing and multiplying in very cold environment like negative 80 degrees Celsius. This proves how stubborn are microbes, which is a reason why people, animals and plants succumb from them if not cleared.
A glance on antibiotics
Thousands of companies are manufacturing antibiotics/ antimicrobial such as antivirals, antifungal and others.
Antimicrobials are developed in order to treat, eliminate and monitor infectious microorganisms. Not forgetting that natural human immunity also play a pivotal role in eliminating and clearing microbes in our body systems.
Keeping in mind that antibiotics have side effects, those effect slightly affect human bodies negatively. Our bodies are like motor vehicles, regularly requires services.
Human body services goes along with the use of antimicrobial agents but the over used of antibiotics lead to microbial resistance to them. How microorganisms resist antibiotics, will be discussed in our next topic.
Good microorganisms go bad too
Microbiotas are not all so bad, some bacteria are good for our health but in excess are dangerous. Microorganisms called normal microflora are not that bad, they protect us from so many things.
Take an example of Mutans streptococcus which is mostly found residing in our mouth. It is responsible for keeping pH balance in our oral environment.
By keeping pH balance, our teeth are protected from an automatic demineralization (breaking down). Despite that, we still get oral conditions such as dental caries which are caused by species of Mutans streptococcus, due to our diet imbalance.
Consumption of sucrose rich nutrients lead to super activation of normal flora (Mutans streptococcus species) microorganisms to multiply excessively and uncontrollable. That way oral infection such as dental caries is manifested.
Looking at a female sex canal, it naturally possess a fungi called Candida Albicans, which is a very good microorganisms but but under unbalance pH environment, the fungal infection immerge, which is called Candidiasis.
Candidiasis cause a discharge through the vagina. Which is a very uncomfortable discharge in a woman’s private part. This fungal infection is infectious, it can be transmitted from one person to another via unprotected sexual activities. We will discuss more of sexual transmitted diseases in the next post.
Commercial uses of microorganisms
Microorganisms that are found residing in our body can be used commercially to manufacture food that we love and eat everyday, for example cheese, yogurt etc. This topic will be discussed later.
humans have both good and bad relationship with microorganisms. Good microorganisms are beneficial to human, while bad ones are harming our health. The over use of antibiotics leads to microbes being resistance.
Any one can get sick due to many unforeseen reasons. You can come across your own normal flora (get details on the next topic); you can come across microorganisms like infectious bacteria from the air, soil, water, and through other human beings.
We are surrounded by trillions of microorganisms that survive in diverse environment. Some of these microorganisms are good for our health and some are very bad, culprits of our death cause. On the following topics we will discuss the basics of microorganisms diversity.
This will include entry into the microbial world, roles of microorganisms in nature, microbial adaptation to diverse environment, microorganisms that plants interact with and use of microbial diversity by humans.
The entry of microbial into the world
Definition of microorganisms diversity, and how are interconnected with one another.Before birth, all normal infants are protected from the environment by the placental of the mother and her immune system.
Immediately, the unborn child decide to escape the womb, that is where an enormously complex microbial world that had evolved past trillions years ago enters or evade an infant.
Most of these microorganisms are free living but a few have ecological niches in the external, mucosal, and other surfaces of humans and other creatures. Often these microorganisms have a mutual benefit.
Few minority became unwelcome guests on human bodies through the expression of specialized features that give them a capacity to injures thus cause an infection. Understanding how microorganisms cause an infection that lead to a diseases is the major goal of this website.
The role of microorganisms in nature
Microorganisms are defined as living things that are invisible to the human unaided eyes, can only be seen by the use of microorganisms.
There are responsible for the breakdown and natural recycling of organic material in the environment. Some can fix atmospheric nitrogen and synthesize nitrogen a containing inorganic and organic compounds that contribute to the nutrition of living things that lack this ability.
Some can use atmospheric carbon dioxide as a source of carbon for organic compounds. Others like oceanic algae produce oxygen through their use of atmospheric carbon dioxide for photosynthesis.
Thus , microorganisms play central roles in the nitrogen and carbon cycles and contribute to maintaining the atmospheric oxygen level.
The microbial adaptation to diverse environment
Microorganisms have amazing range of metabolic and energy yielding ability. Many have an ability to exist under conditions that are lethal to other life forms.
For example, some bacteria can oxidize inorganic compounds such as sulphur and ammonium ions to generate energy. Some can survive and multiply in hot springs at temperature above 75 degrees Celsius.
Many microorganisms can metabolize only fermentatively. Using substances other than oxygen as terminal electron acceptors, and can thus multiply under highly reduced conditions.
Some of these are callulolytic and can multiply rapidly in masses of decaying vegetation in the absence of oxygen. To many, oxygen is lethal.
The microorganisms that plants interact with
Some microbial species have adapted to a symbiotic relationship with higher forms of life. For example, bacteria that can fox atmospheric nitrogen colonize root systems of legumes.
When the plant dies or is plowed under, the fertility of the soil is enhanced by nitrogenous compounds originally derived from the metabolism of the bacteria. These few examples demonstrate the nature of microbial life and their essential place in our ecosystem.
The use of microbial diversity by humans
The metabolic diversity of microorganisms have led to their application to humans purposes. These uses include alcoholic fermentation in the production of wines and beers.Also the production of complex molecules such as vitamin12 and various antibiotics.
Through the use of recombinant DNA techniques, genes encoding the synthesis of substances such as human growth hormone and some immunologic mediators have been added to the genomes of bacteria, or yeasts, which then synthesize the desired products in the culture.
Because of this relatively simple and manipulable genetic structure, molecular biology studies on bacteria continue to help illuminate the complexities of cellular regulation and differentiation in higher life forms.
MICROORGANISMS AND DISEASES
To study microorganisms and their role in nature is very interesting and important.
This website, however has a narrower focus since it only concerned with those microorganisms that are directly involved in the maintenance of human health and causation of infection leading to a diseases.
Within this context, we considers the four broad classes of microorganisms that interact with humans: Bacteria, Fungi, Viruses, and Protozoa.
We will then extend our knowledge to include some multicellular parasites, the helminths and fluke, that are macroscopic at some stages of their life cycles.
The bacteria ate generally smaller, simpler and probably more primitive than the fungi. Their nuclear material comprises of a single, double stranded, but very large DNA molecules withouts a structural nuclear membrane.
There are described as prokaryotic and haploid with nontrue sexual mode of reproduction. They possess autonomous self replicating smaller circular DNA molecules, termed plasmid.
The viruses, are totally different group of infectious agents.
There are strictly intracellular parasites of other living cells.Not only human cells and plants but also for bacteria.
The viruses are simple forms of replication, biological active particles that carry genetic information in either DNA or RNA molecules but never both.
Most matured viruses have protein coat over their nucleic acid and sometimes a lipid surface membrane. Which is derived from the cell that they infect.
They lack the protein synthesizing enzymes and structural apparatus necessary for their own replication. They bear essentially no resemblance to a true eukaryotes or prokaryotic cell.
Viruses replicate by using their genetically active nucleric acids to subvert the metabolic activities of the cell that they infect to bring about the synthesis and reassembly of their component parts.
A cell infected with the single viral particle may thus yield many thousands of viral particles, which can be assembled almost simultaneously under viral nucleic acid.
See the next publication Genomic structures: viruses causing infection and diseases
Who We Are
At [drjiyanemedicalhelp.com], we are committed to maintaining the trust and confidence of all visitors to our web site. In particular, we want you to know that [drjiyanemedicalhelp.com] is not in the business of selling, renting or trading email lists with other companies and businesses for marketing purposes.
We take your privacy seriously and take measures to provide all visitors and users of [drjiyanemedicalhelp.com] with a safe and secure environment.
[drjiyanemedicalhelp.com] may set and access [drjiyanemedicalhelp.com] cookies on your computer. Cookies are used to provide our system with the basic information to provide the services you are requesting. Cookies can be cleared at any time from your internet browser settings.
When someone visits [drjiyanemedicalhelp.com] we use a third party service, Google Analytics, to collect standard internet log information and details of visitor behaviour patterns. We do this to track things such as the number of visitors to the various parts of the site and interactions with the site. This information is processed in a way which does not identify anyone. We do not make, and do not allow Google to make, any attempt to find out the identities of visitors to our website.
When someone visits [drjiyanemedicalhelp.com], there may be an ability to submit comments on particular articles or pages. When comments are submitted, you are entitled to use aliases or information that completely hides your identity. When a comment is submitted, the relevant details (name, email, website) that you provide are stored. These details are stored so that we can display your comment back to you, and to anyone viewing the comment sections on the site. We do not verify information entered nor do we require verification.
There may be some circumstances where your IP address, geographic location, and other browser related details may be shared with third party companies. We may share your above mentioned data with following third party companies from time to time.
Access to Your Personal Information
You are entitled to view, amend, or delete the personal information that we hold. Email your request to our data protection officer [Elliot Zweli Jiyane] at [email@example.com] and we will work with you to remove any of your personal data we may have.